Description

n-(Isothiocyanoacetyl)-(4R)-Benzyl-2-Oxazolidinone is a high-purity chiral auxiliary and synthetic building block of significant importance in asymmetric organic synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, particularly in the synthesis of pharmaceuticals and bioactive compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for advanced synthetic routes.

Application

• Asymmetric Synthesis: Serves as a key chiral auxiliary for the stereocontrolled formation of carbon-carbon and carbon-heteroatom bonds.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), especially those containing β-amino acid derivatives or oxazolidinone motifs.
• Peptidomimetic Research: Facilitates the synthesis of peptide analogs and isosteres due to its isothiocyanate functionality.
• Ligand and Catalyst Development: Acts as a precursor for novel chiral ligands and organocatalysts.
• Agrochemical Synthesis: Employed in creating enantiomerically pure compounds for crop protection agents.
• Academic & Process Chemistry: A valuable tool for methodological development and scale-up studies in academic and industrial R&D laboratories.

Basic Information

Product Name	n-(Isothiocyanoacetyl)-(4R)-Benzyl-2-Oxazolidinone
CAS No.	104324-18-7
Molecular Formula	C₁₃H₁₂N₂O₃S
Molecular Weight	276.31 g/mol
Synonyms	(4R)-4-Benzyl-3-[(isothiocyanatoacetyl)]-2-oxazolidinone; (R)-4-Benzyl-3-(isothiocyanatoacetyl)oxazolidin-2-one; (R)-N-(Isothiocyanatoacetyl)-4-benzyl-2-oxazolidinone; Evans Chiral Auxiliary Derivative; (R)-BOI; N-Isothiocyanatoacetyl-4-benzyl-(R)-oxazolidin-2-one
EINECS	Contact for details

Quality Control

Our n-(Isothiocyanoacetyl)-(4R)-Benzyl-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting standards for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.