Description

3-Cyclohexene-1-Carboxylic Acid, 6-(Chlorocarbonyl)-, Methyl Ester, (1R-Cis)- (9Ci) is a high-value chiral building block and advanced pharmaceutical intermediate. Its unique cis-fused bicyclic structure with a reactive acid chloride group makes it a critical synthon for constructing complex, stereochemically defined molecules. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for synthesizing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of complex drug molecules, especially in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Serves as a versatile starting material for catalytic asymmetric transformations and the construction of stereogenic centers.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, agrochemicals, and performance materials requiring specific stereochemistry.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for developing new synthetic methodologies and exploring structure-activity relationships (SAR).
• Peptidomimetic & Prostaglandin Analog Synthesis: The reactive carbonyl chloride functionality enables its incorporation into larger, biologically active scaffolds.

Basic Information

Item	Details
Product Name	3-Cyclohexene-1-Carboxylic Acid, 6-(Chlorocarbonyl)-, Methyl Ester, (1R-Cis)- (9Ci)
CAS No.	104265-86-3
Molecular Formula	C9H11ClO3
Molecular Weight	202.63 g/mol
Synonyms	(1R,6S)-6-(Chlorocarbonyl)-3-cyclohexene-1-carboxylic acid methyl ester; Methyl (1R,6S)-6-(chlorocarbonyl)-3-cyclohexene-1-carboxylate; (1R-cis)-6-(Chlorocarbonyl)-3-cyclohexene-1-carboxylic acid methyl ester; cis-6-(Chlorocarbonyl)-3-cyclohexene-1-carboxylic acid methyl ester, (1R)-; 3-Cyclohexene-1-carbonyl chloride, 6-(methoxycarbonyl)-, (1R,6S)-rel-; A key chiral bicyclic acid chloride ester.
EINECS	Contact for details

Quality Control

Every batch of 3-Cyclohexene-1-Carboxylic Acid, 6-(Chlorocarbonyl)-, Methyl Ester, (1R-Cis)- (9Ci) is produced and tested under a strict quality management system to ensure high chiral purity and chemical integrity, critical for sensitive synthetic applications. Our quality protocols are designed to meet the exacting standards of pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/Chiral HPLC), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis of the acid chloride functionality. Recommended long-term storage temperature is 2-8°C. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.