Description

5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-2-Naphthalenecarbonyl Chloride is a specialized organic intermediate featuring a sterically hindered tetralin backbone with a highly reactive acid chloride functional group. This compound matters for its role as a critical building block in the synthesis of complex molecules, offering a unique combination of lipophilicity and structural rigidity. It is primarily needed by research and development chemists in the pharmaceutical and advanced materials sectors for creating novel active pharmaceutical ingredients (APIs), liquid crystals, and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Liquid Crystal Synthesis: Serves as a core building block for creating sterically hindered mesogens used in advanced display technologies.
• Functional Polymer Monomer: Used to incorporate rigid, hydrophobic units into specialty polymers for enhanced thermal and mechanical properties.
• Agrochemical Research: Intermediate in the development of new generation pesticides and herbicides with improved environmental profiles.
• Material Science: Employed in the creation of organic semiconductors and photoconductive materials for electronic applications.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules due to its reactive acyl chloride group.

Basic Information

Product Name	5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-2-Naphthalenecarbonyl Chloride
CAS No.	104224-50-2
Molecular Formula	C15H19ClO
Molecular Weight	250.76 g/mol
Synonyms	2-(Chlorocarbonyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene; 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl chloride; Tetramethyltetrahydronaphthalenecarbonyl chloride; TMTHN-COCl; 2-Naphthalenecarbonyl chloride, 5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-
EINECS	Contact for details

Quality Control

Our 5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-2-Naphthalenecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and strong acid/organic solvent nature, keep the container tightly sealed when not in use and away from moisture, bases, and oxidizing agents. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.