Description

Maxacalcitol is a synthetic vitamin D3 analog, specifically a calcitriol derivative, with the CAS registry number 103909-75-7. This compound is of significant pharmaceutical importance due to its potent activity in regulating calcium and phosphate metabolism. It is primarily utilized in the research and development of targeted therapies for conditions related to bone and mineral disorders, such as secondary hyperparathyroidism associated with chronic kidney disease.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in prescription medications for treating secondary hyperparathyroidism.
• Clinical Research: Used in preclinical and clinical studies to investigate its efficacy and safety profile for metabolic bone diseases.
• Drug Formulation Development: Employed in the development of various dosage forms, including injectable solutions and oral formulations.
• Biochemical Research: Acts as a high-affinity ligand in studies of the vitamin D receptor (VDR) signaling pathway and gene regulation.
• Reference Standard: Used as an analytical standard in quality control laboratories for the identification and assay of pharmaceutical products.

Basic Information

Product Name	Maxacalcitol
CAS No.	103909-75-7
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	22-Oxa-1α,25-dihydroxyvitamin D3; 22-Oxacalcitriol; OCT; Maxacalcitol Hydrate; 1α,25-Dihydroxy-22-oxavitamin D3; (1R,3S)-5-[(E)-2-[(1R,3aS,7aR)-1-[(2R)-6-Hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our Maxacalcitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and specific tests for related substances and residual solvents, ensuring it meets high-purity pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water (KF Titration)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.