Description

2'-Deoxy-2',2'-Difluoroguanosine is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel antiviral and anticancer therapeutics, most notably as a key building block for the active metabolite of the drug Gemcitabine. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality raw materials for the production of active pharmaceutical ingredients (APIs) and for investigative studies in medicinal chemistry.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of Gemcitabine (dFdC), a widely used chemotherapeutic agent.
• Antiviral Drug Research: Serves as a building block in the development of nucleoside-based antiviral compounds targeting viral polymerases.
• Oncology Research: Utilized in biochemical and pharmacological studies to investigate mechanisms of action and develop new anticancer nucleoside analogs.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of therapeutic candidates.
• Biochemical Reagent: Used in enzymatic studies and as a substrate or inhibitor for various nucleoside/nucleotide processing enzymes.
• Process Development & Scale-up: Employed in the optimization and scaling of synthetic routes for commercial API production under cGMP guidelines.

Basic Information

Product Name	2'-Deoxy-2',2'-Difluoroguanosine
CAS No.	103882-87-7
Molecular Formula	C10H12F2N5O4
Molecular Weight	303.23 g/mol
Synonyms	2'-Deoxy-2',2'-difluoroguanosine; 2',2'-Difluorodeoxyguanosine; dFdG; 2'-Difluorodeoxyguanosine; 9-[(2R,4R,5R)-3,4-Difluoro-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-amine; Gemcitabine intermediate; β-2'-Deoxy-2',2'-difluoroguanosine; 2'-Difluoroguanosine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2',2'-Difluoroguanosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support development and commercial projects requiring compliance with ICH guidelines and can supply material produced under current Good Manufacturing Practice (cGMP) standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.