Description

2,5-Difluoro-4-Methyl-Benzoylchloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and methyl substituents, which allows for precise tuning of electronic and steric properties in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring a difluoromethylbenzoyl moiety.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores in electronic and display materials.
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine groups into polymers, improving chemical resistance and surface properties.
• Organic Ligand Preparation: Useful for synthesizing specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & R&D: A versatile reagent for medicinal chemistry and process research in contract research and development organizations (CROs/CDMOs).

Basic Information

Product Name	2,5-Difluoro-4-Methyl-Benzoylchloride
CAS No.	103877-56-1
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2,5-Difluoro-4-methylbenzoyl chloride; 4-Methyl-2,5-difluorobenzoyl chloride; Benzoyl chloride, 2,5-difluoro-4-methyl-; 2,5-Difluoro-p-toluoyl chloride; 2,5-Difluoro-4-methylbenzoic acid chloride; α,2,5-Trifluoro-p-toluoyl chloride (archaic); 103877-56-1 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Methyl-Benzoylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing all specification parameters are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Keep under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.