Description

1-Chlorocarbonyl-4-Piperidinopiperidine is a high-value, bifunctional chemical intermediate featuring both a reactive acid chloride group and a piperidine moiety. This compound is critical for the synthesis of complex molecules, particularly in pharmaceutical research and development where it serves as a key building block for active pharmaceutical ingredients (APIs). It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel compounds and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• API (Active Pharmaceutical Ingredient) Synthesis: Used in the construction of the core scaffold or side chains of various APIs, leveraging its reactive chlorocarbonyl group for amide bond formation.
• Agrochemical Research: Serves as an intermediate in the development of new herbicides, fungicides, and insecticides that require a piperidine-based structure.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for producing specialty chemicals with high purity requirements.
• Bioconjugation & Linker Chemistry: The acid chloride functionality allows for efficient conjugation to amines, making it useful in creating chemical linkers for probes and biomolecules.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new chemical spaces in medicinal and synthetic chemistry laboratories.

Basic Information

Product Name	1-Chlorocarbonyl-4-Piperidinopiperidine
CAS No.	103816-19-9
Molecular Formula	C11H19ClN2O
Molecular Weight	230.74 g/mol
Synonyms	4-Piperidinopiperidine-1-carbonyl chloride; 1-Piperidinecarbonyl chloride, 4-(1-piperidinyl)-; 4-(Piperidin-1-yl)piperidine-1-carbonyl chloride; 1-Carbamoyl-4-piperidinopiperidine hydrochloride (related); 4-Piperidin-1-yl-piperidine-1-carbonyl chloride; Isonipecotamide, 4-(1-piperidinyl)-, hydrochloride (related); NSC 339586
EINECS	Contact for details

Quality Control

Every batch of 1-Chlorocarbonyl-4-Piperidinopiperidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and cGMP manufacturing. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.