Description

1(2H)-Quinolinecarbonyl Chloride, 3,4-Dihydro-7-Methyl- (9Ci) is a specialized heterocyclic building block and acid chloride derivative of significant interest in advanced organic synthesis. Its core value lies in its high reactivity, serving as a key precursor for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists in fine chemical manufacturing, where it is used to introduce the quinoline pharmacophore or as an acylating agent. The product, identified by CAS No. 103661-42-3, is supplied under stringent quality controls to ensure reliability for critical synthetic applications.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides, herbicides, and fungicides that incorporate the quinoline scaffold for enhanced biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, organic semiconductors, and advanced coatings.
• Ligand and Catalyst Development: Employed to synthesize complex chelating ligands for metal catalysis and coordination chemistry applications.
• Fluorescent Probe Synthesis: Acts as a precursor for developing quinoline-based fluorescent dyes and sensors used in bioimaging and analytical chemistry.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and for exploring new reaction pathways involving acid chlorides.

Basic Information

Product Name	1(2H)-Quinolinecarbonyl Chloride, 3,4-Dihydro-7-Methyl- (9Ci)
CAS No.	103661-42-3
Molecular Formula	C11H10ClNO
Molecular Weight	207.66 g/mol
Synonyms	7-Methyl-3,4-dihydro-1(2H)-quinolinecarbonyl chloride; 3,4-Dihydro-7-methyl-2H-quinoline-1-carbonyl chloride; 7-Methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl chloride; 1-Carboxy-7-methyl-1,2,3,4-tetrahydroquinoline chloride; Tetrahydro-7-methylquinoline-1-carbonyl chloride; 7-Methyl-1,2,3,4-tetrahydroquinoline-1-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 1(2H)-Quinolinecarbonyl Chloride, 3,4-Dihydro-7-Methyl- (9Ci) is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our production adheres to cGMP principles where applicable, ensuring the material meets the exacting standards required for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.