Description

Icometasone is a synthetic corticosteroid compound with significant pharmacological activity. This high-purity active pharmaceutical ingredient (API) is valued for its potent anti-inflammatory and immunosuppressive properties, making it a critical component in advanced therapeutic formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of specialized dermatological and respiratory medications.

Application

• Pharmaceutical API: Primary use as an active ingredient in topical corticosteroid creams, ointments, and lotions for treating inflammatory skin conditions such as eczema, psoriasis, and dermatitis.
• Respiratory Therapeutics: Key intermediate in the synthesis of inhaled corticosteroids for managing asthma and chronic obstructive pulmonary disease (COPD).
• Veterinary Medicine: Formulation component for anti-inflammatory treatments in veterinary dermatology.
• Research & Development: Standard reference compound for pharmacological studies, receptor binding assays, and metabolic pathway research in academic and industrial labs.
• Drug Discovery: Building block for the synthesis of novel corticosteroid analogs with improved efficacy and safety profiles.

Basic Information

Product Name	Icometasone
CAS No.	103466-73-5
Molecular Formula	C27H37FO6
Molecular Weight	476.58 g/mol
Synonyms	9α-Fluoro-11β,21-dihydroxy-16α,17α-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-11β,21-dihydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; Icomethasone; Icometason; Icometasone (INN); Icometasonum (Latin)
EINECS	Contact for details

Quality Control

Our Icometasone is manufactured under strict quality management systems to ensure it meets the stringent requirements of pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to confirm compliance with in-house specifications aligned with ICH guidelines. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.