Description

N(4)-Hexadecyl-1-Arabinofuranosylcytosine is a synthetic nucleoside analogue with a long-chain alkyl modification. This structural feature is significant for enhancing lipophilicity and cellular membrane permeability, which is critical for targeted therapeutic applications. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for advanced drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and related pathways.
• Lipid-Nucleic Acid Conjugate Development: Acts as a critical precursor for creating lipophilic conjugates aimed at improving drug delivery systems.
• Antiviral Agent Research: Investigated for its potential activity against DNA viruses due to its cytarabine (ara-C) analogue structure.
• Cell Biology Studies: Employed in research to study the effects of modified nucleosides on cell proliferation and apoptosis.

Basic Information

Product Name	N(4)-Hexadecyl-1-Arabinofuranosylcytosine
CAS No.	103426-87-5
Molecular Formula	C25H45N3O5
Molecular Weight	467.64 g/mol
Synonyms	N4-Hexadecyl-ara-C; 1-β-D-Arabinofuranosyl-4-hexadecylaminopyrimidin-2(1H)-one; N4-Cetyl-1-β-D-arabinofuranosylcytosine; N4-Palmityl-ara-C; N4-Hexadecylcytosine arabinoside; C16-ara-C; N4-Cetylcytarabine; N4-Hexadecyl-cytosine β-D-arabinofuranoside
EINECS	Contact for details

Quality Control

Our N(4)-Hexadecyl-1-Arabinofuranosylcytosine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.