Description

5-Iodo-2'-Deoxyuridine 5'-Monophosphate Sodium is a nucleotide analog derivative of thymidine, specifically modified with an iodine atom at the 5-position and a monophosphate group. This compound is a critical biochemical reagent used as a substrate or inhibitor in enzymatic studies, particularly for research involving DNA polymerases, thymidine kinase, and other nucleotide-metabolizing enzymes. It is essential for researchers and manufacturers in the fields of molecular biology, antiviral drug discovery, and biochemical diagnostics.

Application

• Biochemical Research: Acts as a substrate for studying the activity and kinetics of DNA polymerases and reverse transcriptases.
• Enzyme Inhibition Studies: Used to investigate the mechanism of action of thymidine kinase and related enzymes in nucleotide metabolism pathways.
• Antiviral Research: Serves as a reference compound or precursor in the development of nucleoside analog-based antiviral agents.
• Diagnostic Reagent Manufacturing: Employed in the formulation of kits for enzymatic assays and molecular diagnostics.
• Radiochemical Synthesis: Can be used as a precursor for the synthesis of radiolabeled (e.g., I-125) nucleotides for tracer studies.
• Cell Biology: Utilized in studies of DNA synthesis inhibition and cell cycle analysis.

Basic Information

Product Name	5-Iodo-2'-Deoxyuridine 5'-Monophosphate Sodium
CAS No.	103404-69-9
Molecular Formula	C10H11IN2NaO8P
Molecular Weight	459.07 g/mol
Synonyms	5-Iodo-2'-deoxyuridine 5'-monophosphate sodium salt; 5-Iododeoxyuridine monophosphate sodium; Idoxuridine 5'-monophosphate sodium; 5-Iodo-dUMP sodium; IUdRMP sodium; 5-Iodo-2'-deoxyuridylic acid sodium salt; Sodium 5-iodo-2'-deoxyuridine 5'-monophosphate
EINECS	Contact for details

Quality Control

Our 5-Iodo-2'-Deoxyuridine 5'-Monophosphate Sodium is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and diagnostic applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.