Description

Fmoc-L-Leucyl Chloride CAS NO 103321-59-1 is a protected amino acid derivative, specifically an activated ester of leucine, designed for efficient peptide synthesis. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains with high coupling efficiency and minimal racemization. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the production of therapeutic peptides, peptide hormones, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key reagent for the sequential coupling of leucine residues in automated and manual peptide synthesis.
• Pharmaceutical Intermediate: For the research and development of active pharmaceutical ingredients (APIs) in peptide-based therapeutics.
• Bioconjugation: Used to introduce leucine moieties into proteins, antibodies, or other biomolecules for labeling or functionalization.
• Combinatorial Chemistry: A valuable building block in the generation of diverse peptide libraries for drug discovery and screening.
• Academic & Industrial Research: Employed in biochemical and medicinal chemistry research for studying protein structure-function relationships.
• Custom Peptide Production: A fundamental reagent for CROs and CDMOs specializing in the synthesis of custom peptides for clients.

Basic Information

Product Name	Fmoc-L-Leucyl Chloride
CAS No.	103321-59-1
Molecular Formula	C22H24ClNO3
Molecular Weight	385.89 g/mol
Synonyms	Fmoc-Leu-Cl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine chloride; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoyl chloride; Fmoc-L-leucine chloride; Fmoc-Leucyl chloride; N-Fmoc-L-leucine acid chloride; Nα-Fmoc-L-leucine chloride; L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, chloride
EINECS	Contact for details

Quality Control

Our Fmoc-L-Leucyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and our quality management system supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., argon or nitrogen) to prevent hydrolysis and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in dichloromethane, DMF, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.