Description

Fmoc-D-Phenylalanyl Chloride is a high-purity, chiral amino acid derivative specifically engineered for peptide synthesis. This compound is a critical reagent for the efficient, racemization-free introduction of the D-phenylalanine residue under Fmoc solid-phase peptide synthesis (SPPS) protocols. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research requiring precise control over peptide stereochemistry and sequence. The product is supplied as a moisture-sensitive solid, requiring careful handling to maintain its high reactivity and purity.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the automated, stepwise assembly of peptides using the Fmoc protection strategy.
• Pharmaceutical Intermediate: For the research and production of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Development: Enables the creation of non-natural peptide analogs with enhanced stability, bioavailability, or biological activity.
• Bioconjugation: Used to attach peptide sequences to other molecules, surfaces, or biomolecules for diagnostic and therapeutic applications.
• Chemical Biology Research: A vital tool for probing protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-D-Phenylalanyl Chloride
CAS No.	103321-58-0
Molecular Formula	C24H20ClNO4
Molecular Weight	421.87 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl chloride; Fmoc-D-Phe-Cl; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoyl chloride; Fmoc-D-phenylalanine chloride; N-Fmoc-D-phenylalanine acid chloride; Fmoc-D-Phenylalanine Chloride; D-Fmoc-phenylalanyl chloride
EINECS	Contact for details

Quality Control

Our Fmoc-D-Phenylalanyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements, including GMP-grade upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, such as in a glovebox or under a dry inert atmosphere (e.g., nitrogen or argon), to prevent decomposition and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 0.5%
Solubility	Soluble in dichloromethane, DMF, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.