Description

Fmoc-L-Valinyl Chloride CAS NO 103321-53-5 is a high-purity, protected amino acid derivative specifically engineered for peptide synthesis. This compound serves as a critical building block, enabling the efficient and selective introduction of the valine residue under Fmoc-based solid-phase peptide synthesis (SPPS) protocols. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel peptide therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the Fmoc-strategy, facilitating the controlled elongation of peptide chains.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic, oncological, and infectious diseases.
• Bioconjugation: Employed to site-specifically label peptides or attach functional groups for creating peptide-drug conjugates or diagnostic probes.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: Fundamental for studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR) in biochemistry and medicinal chemistry.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-L-Valinyl Chloride
CAS No.	103321-53-5
Molecular Formula	C₂₁H₂₂ClNO₄
Molecular Weight	387.86 g/mol
Synonyms	Fmoc-Val-Cl; Fmoc-L-Valine Chloride; N-(9-Fluorenylmethoxycarbonyl)-L-valinyl Chloride; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-methylbutanoyl Chloride; N-Fmoc-L-valine Chloride; Fmoc-Val-OCl; Fmoc-Valol Chloride; Nα-Fmoc-L-valine Acid Chloride
EINECS	Contact for details

Quality Control

Our Fmoc-L-Valinyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with detailed specifications to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DCM, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.