Description

Fmoc-L-Prolyl Chloride CAS NO 103321-52-4 is a high-purity, protected amino acid derivative specifically engineered for peptide synthesis. This compound serves as a critical building block, enabling the efficient and selective introduction of proline residues under mild conditions while preventing unwanted side reactions. It is an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, stepwise construction of complex peptides, particularly for introducing proline residues with high fidelity.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for synthesizing shorter peptide sequences or peptide fragments.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide drugs targeting various diseases, including metabolic disorders and cancers.
• Bioconjugation and Labeling: Facilitates the site-specific attachment of peptides to other molecules, such as fluorophores, polymers, or solid surfaces, for diagnostic and material science applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Academic and Industrial Research: A fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor ligands.

Basic Information

Item	Detail
Product Name	Fmoc-L-Prolyl Chloride
CAS No.	103321-52-4
Molecular Formula	C₂₁H₂₀ClNO₃
Molecular Weight	369.84 g/mol
Synonyms	Fmoc-Pro-Cl; Fmoc-L-Proline Chloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl Chloride; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carbonyl chloride; N-Fmoc-L-prolyl chloride; Fmoc-Proline Chloride; Nα-Fmoc-L-prolyl chloride; 2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-1-chlorocarbonyl-pyrrolidine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-L-Prolyl Chloride is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and reactive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in dichloromethane, DMF, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.