Description

Fmoc-Ala-Cl CAS NO 103321-50-2 is a key N-Fmoc-protected amino acid chloride derivative used as a crucial building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the efficient and controlled incorporation of alanine residues while providing orthogonal protection for the α-amino group. This reagent is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester precursor for the rapid and high-yield coupling of Fmoc-Alanine.
• Pharmaceutical Intermediates: For the production of active pharmaceutical ingredients (APIs) in peptide drugs, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry Libraries: Used in automated synthesizers to create diverse arrays of peptides for drug discovery and screening.
• Bioconjugation: A reactive handle for site-specifically attaching peptides to other molecules, surfaces, or biomolecules.
• Academic & Industrial Research: A fundamental reagent for studying peptide structure, function, and interactions in biochemistry and molecular biology labs.
• Custom Peptide Service Providers: A core raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Ala-Cl
CAS No.	103321-50-2
Molecular Formula	C19H18ClNO3
Molecular Weight	343.80 g/mol
Synonyms	Fmoc-L-Alanine Chloride; N-(9-Fluorenylmethoxycarbonyl)-L-alanine chloride; (9H-Fluoren-9-yl)methyl (2S)-2-chloro-1-oxo-1-((trichlorophosphoranyl)oxy)propan-2-ylcarbamate; Fmoc-Alanine Chloride; Fmoc-L-Ala-Cl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine acid chloride; N-Fmoc-L-alanyl chloride
EINECS	Contact for details

Quality Control

Our Fmoc-Ala-Cl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for advanced peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and chloride content assay. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis. Keep the material in a dry, well-ventilated area away from incompatible substances.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in dichloromethane, DMF, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.