Description

Fmoc-Gly-Cl CAS NO 103321-49-9 is a key N-protected amino acid chloride derivative used in solid-phase peptide synthesis (SPPS). It serves as a crucial building block for the efficient and controlled introduction of glycine residues under mild conditions. This reagent is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the incorporation of glycine using Fmoc-chemistry protocols.
• Peptide Drug Intermediate Manufacturing: Used in the large-scale production of active pharmaceutical ingredients (APIs) for peptide drugs.
• Combinatorial Chemistry Libraries: Enables the rapid, automated synthesis of diverse glycine-containing peptide sequences for screening.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins with other molecules.
• Research & Development: A fundamental tool in academic and industrial labs for studying peptide structure, function, and interactions.
• Custom Peptide Service Providers: A staple reagent for companies offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Gly-Cl
CAS No.	103321-49-9
Molecular Formula	C17H14ClNO3
Molecular Weight	315.75 g/mol
Synonyms	Fmoc-Glycine Chloride; N-(9-Fluorenylmethoxycarbonyl)glycine Chloride; N-Fmoc-glycine Chloride; (9H-Fluoren-9-yl)methyl (chlorocarbonyl)methylcarbamate; Fmoc-Gly-OH-Cl; Fmoc-Glycine Acid Chloride; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, chloride
EINECS	Contact for details

Quality Control

Our Fmoc-Gly-Cl is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DCM, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.