Description

1H-Pyrazole-4-Carbonyl Chloride is a versatile and highly reactive chemical building block essential for advanced organic synthesis. Its core value lies in its ability to efficiently introduce the pyrazole-carbonyl moiety, a key structural motif in modern pharmaceuticals and agrochemicals. This intermediate is critically needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries to create novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyrazole heterocycles for therapeutic applications.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the pyrazole scaffold imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a building block for creating complex ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional organic materials, dyes, and polymers with specialized properties.
• Custom Synthesis and Contract Manufacturing: A critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Bioconjugation and Probe Chemistry: Its reactive acid chloride group makes it useful for coupling reactions in bioconjugation for creating diagnostic probes or labeled compounds.

Basic Information

Product Name	1H-Pyrazole-4-Carbonyl Chloride
CAS No.	103286-53-9
Molecular Formula	C4H3ClN2O
Molecular Weight	130.53 g/mol
Synonyms	1H-Pyrazole-4-carbonyl chloride; Pyrazole-4-carbonyl chloride; 4-Pyrazolecarbonyl chloride; 1H-Pyrazole-4-carboxylic acid chloride; 4-Carboxypyrazole chloride; Pyrazole-4-carboxylic acid chloride; 1H-Pyrazol-4-ylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-4-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.