Description

5'-o-Dmt-2'-o-Methylguanosine is a key protected nucleoside derivative, essential for the precise synthesis of oligonucleotides. This compound is critical for researchers and manufacturers requiring high-purity building blocks to ensure the fidelity and yield of synthetic RNA and modified oligonucleotide sequences. It is primarily utilized in the pharmaceutical, biotechnology, and academic research sectors for applications in antisense therapy, siRNA development, and diagnostic probe synthesis.

Application

• Oligonucleotide Synthesis: Serves as a vital phosphoramidite precursor in solid-phase synthesis of RNA and modified oligonucleotides.
• Antisense & siRNA Therapeutics: Used in the research and production of therapeutic oligonucleotides targeting specific gene expression.
• Diagnostic Probe Development: Essential for creating high-specificity probes used in molecular diagnostics and genomic research.
• Biochemical Research: A fundamental reagent for studying RNA structure, function, and enzyme interactions in vitro.
• Pharmaceutical Intermediates: Acts as a protected intermediate in the synthesis of more complex nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5'-o-Dmt-2'-o-Methylguanosine
CAS No.	103285-24-1
Molecular Formula	C32H35N5O7
Molecular Weight	601.66 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-methylguanosine; 2'-O-Methyl-5'-O-DMT-guanosine; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine (common protected form); DMT-2'-O-Me-Guanosine; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-; 2'-O-Methyl-5'-O-(4,4'-dimethoxytriphenylmethyl)guanosine
EINECS	Contact for details

Quality Control

Our 5'-o-Dmt-2'-o-Methylguanosine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the exacting standards required for oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical research and cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.