Description

4-Amino-1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One is a sophisticated nucleoside analog derivative, a key building block in advanced pharmaceutical synthesis. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. Its complex, protected structure makes it an essential intermediate for medicinal chemists and pharmaceutical manufacturers requiring high-purity, specialized raw materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of nucleoside-based antiviral and anticancer drugs.
• Antiviral Drug Research: Used in the development of novel therapeutic agents targeting viral polymerases and reverse transcriptases.
• Oligonucleotide Synthesis: Serves as a protected nucleoside phosphoramidite precursor for solid-phase synthesis of DNA/RNA analogs.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to nucleic acid metabolism.
• Precision Chemical Synthesis: Used in the multi-step synthesis of complex, chirally pure bioactive molecules.

Basic Information

Product Name	4-Amino-1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One
CAS No.	103285-21-8
Molecular Formula	C31H33N3O7
Molecular Weight	559.61 g/mol
Synonyms	4-Amino-1-(5-O-(4,4'-Dimethoxytrityl)-2,3-di-O-methyl-β-D-ribofuranosyl)-2(1H)-pyrimidinone; 5'-O-(4,4'-Dimethoxytrityl)-2',3'-di-O-methylcytidine; DMT-2',3'-di-O-methylcytidine; 2',3'-Di-O-methyl-5'-O-(4,4'-dimethoxytrityl)cytidine; Protected 2',3'-di-O-methylcytidine; Nucleoside Derivative CAS 103285-21-8; Cytidine analog with DMT and methyl protections
EINECS	Contact for details

Quality Control

Our 4-Amino-1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., argon or nitrogen) when not in use to prevent degradation and moisture absorption. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.