Description

3'-o-Amino-2'-Deoxycytidine is a modified nucleoside analog of deoxycytidine, featuring a unique amino group substitution at the 3'-O position. This structural modification makes it a valuable intermediate in the synthesis of oligonucleotides and nucleotide-based pharmaceuticals, particularly for antisense and gene therapy research. It is essential for researchers and manufacturers in the fields of pharmaceutical development, molecular biology, and diagnostic reagent production who require high-purity building blocks for advanced therapeutic and diagnostic applications.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel nucleotide-based drugs, including antisense oligonucleotides and prodrugs.
• Antiviral & Anticancer Research: Used in the development of nucleoside analogs that target viral replication or cancer cell proliferation.
• Oligonucleotide Synthesis: Serves as a modified monomer in solid-phase synthesis for creating research-grade and therapeutic oligonucleotides.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate DNA/RNA metabolism and repair mechanisms.
• Diagnostic Probe Development: Utilized in the design and manufacture of labeled probes for genetic testing and molecular diagnostics.
• Academic & Institutional Research: A critical reagent for universities and research institutes exploring nucleic acid chemistry and medicinal chemistry.

Basic Information

Product Name	3'-o-Amino-2'-Deoxycytidine
CAS No.	103251-39-4
Molecular Formula	C9H14N4O4
Molecular Weight	242.23 g/mol
Synonyms	3'-Amino-2'-deoxycytidine; 2'-Deoxy-3'-O-aminocytidine; 1-(2-Deoxy-3-O-amino-β-D-ribofuranosyl)cytosine; 3'-O-Amino-2'-deoxycytidine; 3'-Amino-2'-deoxycytidine; 3'-O-NH2-2'-dC; 3'-Amino-dC; Amino-modified deoxycytidine nucleoside
EINECS	Contact for details

Quality Control

Our 3'-o-Amino-2'-Deoxycytidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.