Description

3'-o-Aminothymidine is a modified nucleoside derivative, a key building block in oligonucleotide synthesis and pharmaceutical research. Its primary value lies in its role as a versatile intermediate for creating modified DNA/RNA sequences, enabling advanced studies in antisense therapy, diagnostics, and molecular biology. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity, specialized nucleosides for drug discovery and development.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified antisense oligonucleotides and aptamers.
• Pharmaceutical Intermediates: Serves as a key building block in the research and development of novel nucleoside-based therapeutics, including antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate DNA/RNA metabolism and repair mechanisms.
• Probe Development: Facilitates the creation of labeled DNA probes for diagnostic assays, fluorescence in situ hybridization (FISH), and genomic research.
• Academic & Industrial R&D: Employed in universities, research institutes, and corporate R&D labs for fundamental studies in genetics and molecular biology.

Basic Information

Item	Details
Product Name	3'-o-Aminothymidine
CAS No.	103251-38-3
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	3'-Amino-3'-deoxythymidine; 3'-Amino-2',3'-dideoxythymidine; 1-[(2R,4S,5R)-4-Amino-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 3'-Amino-ddT; 3'-NH2-ddT; 3'-Amino-2',3'-dideoxy-5-methyluridine; 3'-Amino-5-methyl-2',3'-dideoxyuridine
EINECS	Contact for details

Quality Control

Our 3'-o-Aminothymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.