Description

Guanylyl(2'-5')Cytidine Ammonium is a specialized dinucleoside monophosphate analog, a key building block in oligonucleotide synthesis and biochemical research. This compound is of significant interest for studying the structure, function, and therapeutic potential of non-canonical nucleic acid linkages. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced molecular biology, antiviral research, and the development of novel nucleic acid-based therapeutics.

Application

• Oligonucleotide Synthesis: Serves as a crucial phosphoramidite precursor or intermediate for constructing oligonucleotides containing unique 2'-5' internucleotide linkages.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the activity and mechanism of ribonucleases, polymerases, and other nucleic acid-modifying enzymes.
• Antiviral Mechanism Studies: Employed in research focused on the 2-5A (2',5'-oligoadenylate) pathway, a part of the innate immune response to viral infection.
• Structural Biology: Provides a model compound for X-ray crystallography or NMR studies to determine the three-dimensional structure of 2'-5' linked RNA analogs.
• Therapeutic Development: Acts as a starting material or reference standard in the R&D of novel antisense oligonucleotides, siRNA, or aptamers with modified backbones for enhanced stability and specificity.

Basic Information

Product Name	Guanylyl(2'-5')Cytidine Ammonium
CAS No.	103213-37-2
Molecular Formula	C19H28N9O12P • xNH3
Molecular Weight	605.46 g/mol (Free acid, anhydrous basis)
Synonyms	2'-5'-GpC ammonium salt; Guanylyl(2'→5')cytidine ammonium salt; G(2'-5')C ammonium; 2',5'-Oligoadenylate core structure analog; 5'-O-Phosphonoguanylyl-(2'→5')-cytidine ammonium salt; P1-Guanosine-5'-yl P2-cytidine-2'-yl ester ammonium salt; Ammonium 5'-guanylyl(2'→5')cytidine
EINECS	Contact for details

Quality Control

Our Guanylyl(2'-5')Cytidine Ammonium is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and MS, are validated to provide reliable specifications for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Ammonium Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.