Description

Guanosine 2',3'-Dialdehyde 5'-Phosphate is a chemically modified nucleotide derivative, specifically a dialdehyde derivative of guanosine monophosphate. This compound is a valuable biochemical reagent and synthetic intermediate, primarily used in cross-linking and bioconjugation applications due to its reactive aldehyde groups. It is essential for researchers and manufacturers in the fields of nucleic acid chemistry, bioconjugation, and pharmaceutical development, where precise molecular modification is required.

Application

• Bioconjugation and Cross-linking Agent: Used to covalently link biomolecules (e.g., proteins, peptides, oligonucleotides) via Schiff base formation with primary amines.
• Nucleic Acid Research: Serves as a key intermediate in the synthesis of modified nucleotides and oligonucleotides for structural and functional studies.
• Pharmaceutical Development: Employed in the research and development of nucleotide-based therapeutics and prodrugs.
• Diagnostic Reagent Synthesis: Used in the preparation of labeled probes and other reagents for diagnostic assays.
• Enzyme Immobilization: Acts as a linker for immobilizing enzymes or other proteins onto solid supports for biocatalysis.
• Material Science: Potential use in creating functionalized surfaces or polymers with nucleotide motifs.

Basic Information

Product Name	Guanosine 2',3'-Dialdehyde 5'-Phosphate
CAS No.	103192-44-5
Molecular Formula	C10H12N5O10P
Molecular Weight	393.20 g/mol
Synonyms	2',3'-O-Diformylguanosine 5'-Monophosphate; Guanosine 5'-Monophosphate 2',3'-Dialdehyde; GDP Dialdehyde; 2',3'-Dialdehyde Guanosine 5'-Phosphate; Periodate-Oxidized Guanosine 5'-Monophosphate; GMP Dialdehyde; 5'-GMP 2',3'-Dialdehyde; 2',3'-Dicarboxyaldehyde Guanosine 5'-Phosphate
EINECS	Contact for details

Quality Control

Our Guanosine 2',3'-Dialdehyde 5'-Phosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, identity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.