Description

5'-Deoxy-5'-Iodo-9-Deazainosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. Its unique structure, featuring a deoxy-iodo substitution and a deaza modification, makes it a valuable intermediate for the synthesis of novel antiviral and anticancer agents. This high-purity compound is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on nucleoside chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based therapeutics targeting viral infections and oncology.
• Antiviral Drug Research: Used in the development of potential antiviral agents, particularly for DNA viruses, by acting as a chain terminator or inhibitor of viral polymerases.
• Oncology Research: Serves as a building block for creating purine nucleoside analogs that interfere with cancer cell DNA/RNA synthesis.
• Biochemical Probe: Employed in enzymatic studies to investigate the substrate specificity and mechanism of nucleoside-processing enzymes like kinases and phosphorylases.
• Medicinal Chemistry SAR Studies: Utilized for structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside drug candidates.
• Labeled Compound Synthesis: Acts as a starting material for the synthesis of radiolabeled (e.g., with I-125) or fluorescently tagged nucleosides for diagnostic and tracking applications.

Basic Information

Product Name	5'-Deoxy-5'-Iodo-9-Deazainosine
CAS No.	102731-46-4
Molecular Formula	C11H12IN5O3
Molecular Weight	389.15 g/mol
Synonyms	9-Deaza-5'-deoxy-5'-iodoinosine; 5'-Iodo-5'-deoxy-9-deazainosine; 9H-Purin-9-one, 1,6-dihydro-5-iodo-2-methoxy-6-(1-methylethenyl)-; 5'-Deoxy-5'-iodo-9-deazainosine; 9-Deazainosine, 5'-deoxy-5'-iodo-; 5'-Iodo-5'-deoxy-9-deazainosine
EINECS	Contact for details

Quality Control

Our 5'-Deoxy-5'-Iodo-9-Deazainosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.