Description

7-Deazaguanosine is a purine nucleoside analog where a carbon atom replaces the nitrogen atom at the 7-position of the guanine base. This structural modification makes it a valuable biochemical tool and synthetic intermediate for studying nucleic acid structure, function, and inhibition. It is primarily utilized in pharmaceutical research and development, particularly in the design of antiviral and anticancer agents. Key industries requiring this compound include biotechnology, academic research, and fine chemical synthesis.

Application

• Biochemical Research: Used as a key intermediate in the synthesis of nucleoside analogs for studying enzyme mechanisms and nucleic acid interactions.
• Antiviral Drug Development: Serves as a building block for creating novel therapeutic agents targeting viral polymerases and replication.
• Oncology Research: Investigated for the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Molecular Biology: Employed in the study of RNA structure, stability, and function, including research on tRNA and ribozymes.
• Diagnostic Reagent Synthesis: Used in the preparation of labeled probes and other diagnostic compounds.
• Fine Chemical Synthesis: Acts as a specialized intermediate for the custom synthesis of complex organic molecules in contract research and manufacturing.

Basic Information

Product Name	7-Deazaguanosine
CAS No.	102731-45-3
Molecular Formula	C11H14N4O5
Molecular Weight	282.25 g/mol
Synonyms	7-Carbaguanosine; Tubercidin analog; 7-Cyano-7-deazaguanosine; 4-Amino-5-cyano-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; Pyrrolo[2,3-d]pyrimidine nucleoside; PreQ0 nucleoside; 7-Deaza-guanosine
EINECS	Contact for details

Quality Control

Our 7-Deazaguanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to ensure compliance with your research and development requirements. Our quality commitment supports applications demanding high-purity biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.