Description

1-(4-Isothiocyanatobenzyl)Diethylenetriaminepentaacetic Acid is a bifunctional chelating agent that combines a strong metal-chelating DTPA moiety with a reactive isothiocyanate group for covalent conjugation. This compound matters for its critical role in creating stable, site-specific metal complexes, primarily for diagnostic and research applications. It is essential for manufacturers and researchers in the fields of radiopharmaceuticals, molecular imaging, and advanced immunoassays who require reliable and high-purity conjugation linkers.

Application

• Radiopharmaceutical Precursor: Key intermediate for labeling monoclonal antibodies, peptides, and other biomolecules with diagnostic radionuclides like Indium-111 or Technetium-99m for SPECT imaging.
• Contrast Agent Development: Used in the synthesis of gadolinium-based contrast agents for Magnetic Resonance Imaging (MRI).
• Immunoassay Reagent: Conjugation linker for attaching metal ions or fluorescent probes to antibodies and proteins in diagnostic assay development.
• Research Chemical: Tool compound in chemical biology and inorganic chemistry for studying metal-ligand interactions and developing novel chelation systems.
• Therapeutic Agent Conjugation: Potential use in creating targeted therapeutic radiopharmaceuticals for cancer treatment (theranostics).

Basic Information

Product Name	1-(4-Isothiocyanatobenzyl)Diethylenetriaminepentaacetic Acid
CAS No.	102650-30-6
Molecular Formula	C23H30N4O10S
Molecular Weight	554.57 g/mol
Synonyms	p-SCN-Bn-DTPA; 1-(p-Isothiocyanatobenzyl)diethylenetriaminepentaacetic acid; 2-[Bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid, 4-isothiocyanatobenzyl ester; DTPA-isothiocyanate; Bz-DTPA-SCN; (4-Isothiocyanatobenzyl)-DTPA; SCN-Bz-DTPA; Chelating agent DTPA-NCS
EINECS	Contact for details

Quality Control

Our 1-(4-Isothiocyanatobenzyl)Diethylenetriaminepentaacetic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.