Description

Cytidylyl(2'5')Guanosine Ammonium is a high-purity nucleotide derivative, specifically a 2'-5' linked dinucleoside monophosphate. This compound is of significant value in biochemical and pharmaceutical research for studying RNA structure, function, and the mechanisms of oligonucleotide synthesis. It serves as a critical building block and reference standard for researchers and manufacturers in the fields of nucleic acid chemistry, antiviral drug development, and molecular biology diagnostics.

Application

• Biochemical Research: Used as a substrate or intermediate in enzymatic studies, particularly those involving RNA ligases and polymerases.
• Pharmaceutical Development: Acts as a key precursor or reference standard in the synthesis and quality control of novel antiviral and antisense oligonucleotide therapeutics.
• Diagnostic Reagent Manufacturing: Employed in the production of probes and primers for molecular diagnostics, including PCR and sequencing applications.
• Enzyme Mechanism Studies: Serves as a tool to investigate the specificity and kinetics of enzymes that process or recognize non-canonical 2'-5' phosphodiester linkages.
• Academic Research: Utilized in universities and research institutes for fundamental studies on RNA biology, interferon action pathways, and oligonucleotide chemistry.
• Reference Standard: Provides a high-purity calibrant for analytical methods (HPLC, MS) used in quality control laboratories for nucleic acid-based products.

Basic Information

Product Name	Cytidylyl(2'5')Guanosine Ammonium
CAS No.	102601-47-8
Molecular Formula	C19H28N9O13P • xNH3
Molecular Weight	645.46 g/mol (free acid, anhydrous basis)
Synonyms	2'-5' CpG ammonium salt; Cytidylyl-(2'→5')-guanosine ammonium salt; 2'-5'-Cytidylguanosine ammonium; pC(2'-5')G ammonium; CpG (2'-5') dinucleotide ammonium salt; 5'-O-Phosphonocytidylyl-(2'→5')-guanosine ammonium; Guanosine, 5'-[3-O-[5-O-[(4-amino-2-oxo-1(2H)-pyrimidinyl)methyl]-2-O-phosphono-β-D-ribofuranosyl] hydrogen phosphate], ammonium salt
EINECS	Contact for details

Quality Control

Our Cytidylyl(2'5')Guanosine Ammonium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Ammonium Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.