Description

1-(β-D-Arabinofuranosyl)-4-o-Difluoromethyluracil is a modified nucleoside analog, a key building block in advanced pharmaceutical research and development. This compound is valued for its role as a versatile intermediate in the synthesis of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in the development of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of experimental antiviral drugs targeting viral polymerases.
• Anticancer Research: Used in the development of novel chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand nucleoside metabolism and related pathways.
• Prodrug Development: Employed in the design and synthesis of prodrugs to enhance the bioavailability and targeting of active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1-(β-D-Arabinofuranosyl)-4-o-Difluoromethyluracil
CAS No.	102302-66-9
Molecular Formula	C11H13F2N2O6
Molecular Weight	307.23 g/mol
Synonyms	4-(Difluoromethyl)-1-β-D-arabinofuranosyluracil; 1-β-D-Arabinofuranosyl-4-(difluoromethyl)uracil; 4-(Difluoromethyl)-1-β-D-arabinofuranosyl-2,4(1H,3H)-pyrimidinedione; Arabinofuranosyl Difluoromethyluracil; β-D-Arabinofuranosyl-4-difluoromethyluracil; 4-Difluoromethyl-1-β-D-arabinofuranosyluracil
EINECS	Contact for details

Quality Control

Our 1-(β-D-Arabinofuranosyl)-4-o-Difluoromethyluracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.