Description

8-Bromoguanosine 5'-Monophosphate Sodium Salt is a chemically modified nucleotide monophosphate, serving as a crucial building block and biochemical tool. This compound is essential for researchers and manufacturers requiring site-specific modification of nucleic acids or probing enzymatic mechanisms. It is primarily utilized in pharmaceutical research, oligonucleotide synthesis, and biochemical studies where the bromine moiety acts as a reactive handle for further functionalization or as a spectroscopic label.

Application

• Oligonucleotide Synthesis: Key intermediate for incorporating modified bases into synthetic DNA/RNA strands for therapeutic and diagnostic applications.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies of kinases, polymerases, and other nucleotide-processing enzymes.
• Pharmaceutical Development: Serves as a precursor in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Structural Biology: Employed in X-ray crystallography and NMR studies to investigate nucleic acid structure and protein-nucleic acid interactions.
• Cross-linking Agent: The bromine atom can be utilized in photo-affinity labeling or cross-linking experiments to study biomolecular interactions.
• Diagnostic Probe Development: Acts as a component in the creation of labeled probes for detecting specific DNA or RNA sequences.

Basic Information

Product Name	8-Bromoguanosine 5'-Monophosphate Sodium Salt
CAS No.	102213-02-5
Molecular Formula	C10H12BrN5NaO8P
Molecular Weight	472.10 g/mol
Synonyms	8-Bromo-GMP Sodium Salt; 8-Br-GMP Na; Sodium 8-Bromoguanosine 5'-Monophosphate; 8-Bromoguanosine 5'-(dihydrogen phosphate) monosodium salt; 8-Bromo-5'-GMP sodium salt; GMP-8-Br, sodium salt; 8-Bromoguanosine 5'-phosphate sodium salt
EINECS	Contact for details

Quality Control

Our 8-Bromoguanosine 5'-Monophosphate Sodium Salt is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.