Description

8-Bromoadenosine 5'-Diphosphate Sodium is a chemically modified nucleotide analog where a bromine atom is introduced at the 8-position of the adenine ring. This modification is crucial for its role as a potent and selective antagonist of P2Y1 purinergic receptors, making it a vital tool for studying platelet aggregation, cardiovascular signaling, and other ADP-mediated physiological processes. It is primarily utilized by researchers and developers in pharmaceutical R&D, biochemical research, and diagnostic assay development who require high-purity, well-characterized nucleotide derivatives for mechanistic studies and screening applications.

Application

• Biochemical Research: As a selective P2Y1 receptor antagonist to investigate purinergic signaling pathways in cardiovascular, neurological, and immune systems.
• Platelet Aggregation Studies: Used in vitro to inhibit ADP-induced platelet activation, aiding in the study of thrombosis and hemostasis.
• Enzymology: Serves as a substrate analog or inhibitor for studies involving nucleotide-metabolizing enzymes like kinases, phosphatases, and nucleotidases.
• Pharmaceutical Development: A key reference compound in the discovery and screening of novel antiplatelet and antithrombotic drug candidates.
• Diagnostic Reagent Manufacturing: Incorporated into specialized assay kits for clinical research and diagnostic testing related to platelet function.
• Cell Signaling Research: Employed to dissect the role of extracellular nucleotides in cellular communication and receptor pharmacology.

Basic Information

Product Name	8-Bromoadenosine 5'-Diphosphate Sodium
CAS No.	102185-47-7
Molecular Formula	C10H12BrN5O10P2Na2 or C10H12BrN5O10P2·xNa
Molecular Weight	Contact for details
Synonyms	8-Br-ADP Sodium Salt; 8-Bromo-ADP Sodium; Adenosine 5'-(trihydrogen diphosphate), 8-bromo-, sodium salt; 8-Bromoadenosine-5'-diphosphate sodium; P1-(8-Bromoadenosine-5')-P2-diphosphate sodium salt; 8-BrADP Na; BADP Sodium Salt
EINECS	Contact for details

Quality Control

Our 8-Bromoadenosine 5'-Diphosphate Sodium is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A detailed Certificate of Analysis (COA) documenting identity, purity, and specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.