Description

8-Azidoadenosine-5'-o-Diphosphate Sodium Salt is a chemically modified nucleotide analog that serves as a critical biochemical tool. Its value lies in the photoreactive azido group, enabling photoaffinity labeling and cross-linking studies of nucleotide-binding proteins and enzymes. This compound is essential for researchers and manufacturers in biochemistry, molecular biology, and pharmaceutical development, particularly for investigating ATP-dependent processes and enzyme mechanisms.

Application

• Photoaffinity Labeling Probe: Used to covalently tag and identify ATP-binding sites in proteins, enzymes, and receptors upon UV irradiation.
• Enzyme Mechanism Studies: Acts as a substrate analog to investigate the kinetics and catalytic mechanisms of kinases, synthetases, and other ATP-utilizing enzymes.
• Bioconjugation & Cross-linking: Serves as a key reagent for the site-specific modification of biomolecules via click chemistry (e.g., with alkynes) for creating probes or immobilized ligands.
• Structural Biology: Aids in the structural analysis of protein-nucleotide complexes through cross-linking for X-ray crystallography or cryo-EM studies.
• Drug Discovery Target Validation: Employed in high-throughput screening assays to discover and characterize novel inhibitors targeting nucleotide-binding pockets.
• Diagnostic Assay Development: Used in the development of sensitive detection kits and assays for enzymatic activity and biomarker detection.

Basic Information

Product Name	8-Azidoadenosine-5'-o-Diphosphate Sodium Salt
CAS No.	102185-14-8
Molecular Formula	C10H12N8O12P2Na2 • xH2O
Molecular Weight	Anhydrous: 552.16 g/mol
Synonyms	8-N3-ADP Sodium Salt; 8-Azido-ADP Na Salt; 8-Azidoadenosine 5'-diphosphate sodium salt; Adenosine 5'-(trihydrogen diphosphate), 8-azido-, sodium salt (1:2); 8-Azido-ADP; 8-Azido-adenosine-5'-diphosphate; Photo-ADP
EINECS	Contact for details

Quality Control

Our 8-Azidoadenosine-5'-o-Diphosphate Sodium Salt is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term stability, store desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Identification (UV)	Conforms
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 90% (anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.