Description

3-Deazaneplanocin is a potent and selective inhibitor of S-adenosylhomocysteine hydrolase (SAH hydrolase), a key enzyme in cellular methylation processes. This compound is a critical research tool for investigating epigenetic regulation, RNA processing, and viral replication mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, virology, and metabolic disease research.

Application

• Epigenetics Research: As an SAH hydrolase inhibitor, it is used to study the role of methylation in gene expression and chromatin remodeling.
• Antiviral Studies: Investigated for its potential to inhibit the replication of viruses that are dependent on host methylation machinery.
• Cancer Research: Employed in preclinical studies to evaluate its effects on tumor cell growth and proliferation via epigenetic modulation.
• Biochemical Assay Development: Serves as a reference standard and key reagent in high-throughput screening assays targeting methyltransferases.
• Neuropharmacology: Used in research models to understand the role of methylation in neurological function and disease.
• Intermediate for Analog Synthesis: Acts as a sophisticated building block for the chemical synthesis of novel nucleoside analogs with potential therapeutic activity.

Basic Information

Product Name	3-Deazaneplanocin
CAS No.	102052-95-9
Molecular Formula	C₁₂H₁₄N₄O₄
Molecular Weight	278.26 g/mol
Synonyms	3-Deazaneplanocin A; DZNep; 3-Deazaadenosine, 9-(1S,2R,3S,5R)-5-(hydroxymethyl)-3,4-cyclopentanediol-1-yl)-; (-)-3-Deazaneplanocin A; 3-Deazaneplanocin hydrochloride (salt forms); NSC 617989; SAH Hydrolase Inhibitor III; 3-Deaza-DHCeA
EINECS	Contact for details

Quality Control

Our 3-Deazaneplanocin is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for advanced research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.