Description

2-Difluoromethoxyphenyl Isothiocyanate is a specialized aromatic isothiocyanate derivative, distinguished by the presence of a difluoromethoxy substituent. This compound serves as a critical high-purity synthetic intermediate for constructing complex molecular architectures in advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Chemical Biology Probe Synthesis: Employed to create isothiocyanate-functionalized probes for labeling and studying proteins or other biomolecules.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of advanced polymers with specific fluorinated properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in catalytic systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific R&D projects.

Basic Information

Product Name	2-Difluoromethoxyphenyl Isothiocyanate
CAS No.	101856-90-0
Molecular Formula	C8H5F2NOS
Molecular Weight	201.19 g/mol
Synonyms	1-Isothiocyanato-2-(difluoromethoxy)benzene; 2-(Difluoromethoxy)phenyl Isothiocyanate; o-(Difluoromethoxy)phenyl Isothiocyanate; (2-Difluoromethoxyphenyl) Isothiocyanate; Benzene, 1-isothiocyanato-2-(difluoromethoxy)-; DFMP-ITC; 2-DFMP-NCS
EINECS	Contact for details

Quality Control

Every batch of 2-Difluoromethoxyphenyl Isothiocyanate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.