Description

Butenafine CAS NO 101828-21-1 is a synthetic allylamine derivative with potent antifungal activity. This compound is a critical active pharmaceutical ingredient (API) valued for its broad-spectrum efficacy against dermatophytes and yeasts. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of topical antifungal treatments for conditions such as athlete's foot, ringworm, and cutaneous candidiasis.

Application

• Topical Antifungal Creams and Ointments: Primary active ingredient for treating tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate in the production of advanced antifungal drug formulations.
• Veterinary Medicine: Used in topical preparations for treating fungal skin infections in animals.
• Research & Development: A standard compound in microbiological and pharmacological research for studying antifungal mechanisms and resistance.
• Cosmeceutical Products: Incorporated into specialized foot care powders and sprays for antifungal and deodorizing purposes.

Basic Information

Product Name	Butenafine
CAS No.	101828-21-1
Molecular Formula	C23H27N
Molecular Weight	317.47 g/mol
Synonyms	Butenafine; Butenafine HCl; (E)-N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine; N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine; KP-363; Mentax (brand name); (E)-Butenafine; N-Methyl-N-(4-tert-butylbenzyl)-1-naphthalenemethylamine
EINECS	Contact for details

Quality Control

Our Butenafine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) are provided and can be tailored to meet specific pharmacopeial requirements (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.