Description

N2-Ethyl-2'-Deoxyguanosine is a modified nucleoside analog of deoxyguanosine, where an ethyl group is substituted at the N2 position of the guanine base. This specific structural modification is critical for research in nucleic acid chemistry, enabling the study of mutagenesis, DNA adduct formation, and the development of novel therapeutic agents. It is an essential building block and reference standard for pharmaceutical R&D, academic research, and diagnostic development in the life sciences sector.

Application

• Biomedical Research: Used as a key intermediate and reference standard in studies of DNA alkylation damage, mutagenesis, and repair mechanisms.
• Antiviral/Anticancer Drug Development: Serves as a crucial precursor in the synthesis of nucleoside analog prodrugs targeting viral polymerases and cellular replication pathways.
• Diagnostic Assay Development: Employed in the creation of calibration standards and probes for detecting specific DNA lesions or adducts in analytical and diagnostic kits.
• Chemical Biology & Proteomics: Acts as a molecular tool for investigating protein-nucleic acid interactions and enzyme specificity related to nucleotide metabolism.
• Standards & Metrology: Provides a high-purity certified reference material (CRM) for quality control and analytical method validation in regulatory and forensic laboratories.

Basic Information

Product Name	N2-Ethyl-2'-Deoxyguanosine
CAS No.	101803-03-6
Molecular Formula	C12H17N5O4
Molecular Weight	295.30 g/mol
Synonyms	2'-Deoxy-N2-ethylguanosine; N2-Ethyl-2'-deoxyguanosine; N2-Ethyl-2'-deoxyguanosine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(ethylamino)-2-oxo-1H-pyrimidin-5-one; N2-Ethyl-dG; Ethyl-dG; N2-EtdG
EINECS	Contact for details

Quality Control

Every batch of N2-Ethyl-2'-Deoxyguanosine is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.