Description

α-Monofluorothymidine is a fluorinated nucleoside analog of significant interest in pharmaceutical research and development. This compound is valued for its role as a key intermediate and a potential active pharmaceutical ingredient (API) in the synthesis of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the development of targeted therapies, diagnostic probes, and biochemical research tools.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidine kinase and DNA synthesis pathways.
• Radiopharmaceutical Precursor: Serves as a precursor for the synthesis of fluorinated tracers used in Positron Emission Tomography (PET) imaging.
• Antiviral Agent Development: Investigated for its potential activity against viral infections by targeting viral DNA replication.
• Oncology Research: Studied for its cytotoxic properties and potential to inhibit the growth of cancer cells.
• Molecular Probe Synthesis: Utilized to create labeled compounds for studying cellular uptake and metabolic pathways.

Basic Information

Product Name	α-Monofluorothymidine
CAS No.	101527-45-1
Molecular Formula	C10H13FN2O5
Molecular Weight	260.22 g/mol
Synonyms	1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)thymine; 2'-Fluoro-5-methyl-β-D-arabinofuranosyluracil; FMAU; 2'-FMAU; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil; Alovudine; 2'-Fluoro-5-methylarabinofuranosyluracil; FLT (context-dependent)
EINECS	Contact for details

Quality Control

Our α-Monofluorothymidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.