Description

n-[(3S,4R)-1-[2-(4-Isothiocyanatophenyl)Ethyl]-3-Methyl-4-Piperidyl]-N -Phenyl-Propanamide is a high-purity, synthetically derived chemical intermediate featuring a reactive isothiocyanate group. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of targeted small molecule drugs and diagnostic agents. It is primarily required by R&D laboratories and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for creating novel therapeutic entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and receptor-targeted therapies.
• Bioconjugation Reagent: Utilized for labeling proteins, antibodies, or peptides via its reactive isothiocyanate (-N=C=S) group, which couples with amine groups.
• Proteomics Research: Serves as a tool compound in chemical proteomics for studying protein function, interactions, and activity-based protein profiling (ABPP).
• Diagnostic Agent Synthesis: Used in the development of contrast agents or molecular probes for imaging techniques.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities within drug discovery pipelines.
• Ligand Development: Acts as a precursor for creating high-affinity ligands for various biological targets, including G-protein-coupled receptors (GPCRs).

Basic Information

Product Name	n-[(3S,4R)-1-[2-(4-Isothiocyanatophenyl)Ethyl]-3-Methyl-4-Piperidyl]-N -Phenyl-Propanamide
CAS No.	101472-20-2
Molecular Formula	C24H29N3OS
Molecular Weight	407.57 g/mol
Synonyms	N-[(3S,4R)-1-[2-(4-Isothiocyanatophenyl)ethyl]-3-methyl-4-piperidinyl]-N-phenylpropanamide; Propanamide, N-[(3S,4R)-1-[2-(4-isothiocyanatophenyl)ethyl]-3-methyl-4-piperidinyl]-N-phenyl-; 101472-20-2; (3S,4R)-1-[2-(4-Isothiocyanatophenyl)ethyl]-3-methyl-N-phenyl-N-(4-piperidinyl)propanamide; N-Phenyl-N-[(3S,4R)-1-[2-(4-isothiocyanatophenyl)ethyl]-3-methyl-4-piperidyl]propanamide; Fentanyl isothiocyanate derivative; 4'-Isothiocyanatofentanyl
EINECS	Contact for details

Quality Control

Our n-[(3S,4R)-1-[2-(4-Isothiocyanatophenyl)Ethyl]-3-Methyl-4-Piperidyl]-N -Phenyl-Propanamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.