Description

5'-Iodoacetamido-5'-Deoxythymidine is a modified nucleoside derivative, specifically a thymidine analog functionalized with an iodoacetamido group at the 5' position. This compound is a critical biochemical tool and a versatile intermediate for the synthesis of more complex molecular probes and therapeutic agents. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, life sciences, and chemical biology for applications such as bioconjugation, enzyme inhibition studies, and the development of targeted drug delivery systems.

Application

• Bioconjugation Reagent: Used to selectively modify cysteine residues in proteins, peptides, and antibodies for labeling, immobilization, or functionalization.
• Enzyme Inhibitor Synthesis: Serves as a key intermediate in the development of mechanism-based inhibitors for nucleoside-metabolizing enzymes like thymidylate synthase.
• Antiviral/Anticancer Prodrug Development: Acts as a precursor for synthesizing nucleoside analogs with potential therapeutic activity against viral infections and cancers.
• Chemical Biology Probes: Employed in the creation of activity-based probes to study enzyme function and localization within biological systems.
• Oligonucleotide Modification: Used to introduce reactive handles or reporter groups into synthetic DNA strands for diagnostic and research applications.
• Cross-linking Studies: Facilitates the study of protein-nucleic acid interactions and macromolecular complex structures.

Basic Information

Product Name	5'-Iodoacetamido-5'-Deoxythymidine
CAS No.	101314-73-2
Molecular Formula	C12H16IN3O5
Molecular Weight	409.18 g/mol
Synonyms	5'-Deoxy-5'-[(iodoacetyl)amino]thymidine; 5'-Iodoacetamidothymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 5'-(2-iodoacetamide); 5'-(2-Iodoacetamido)-5'-deoxythymidine; 5'-Deoxythymidine, 5'-iodoacetamide; Iodoacetamido-deoxythymidine; Thymidine 5'-iodoacetamide derivative
EINECS	Contact for details

Quality Control

Our 5'-Iodoacetamido-5'-Deoxythymidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.