Description

3'--Amino-2',3'-Dideoxyuridine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and cellular DNA replication. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the development of nucleoside-based therapeutics. The compound, with CAS number 101062-04-8, is valued for its role in creating prodrugs and exploring structure-activity relationships in medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of compounds targeting viruses such as HIV, hepatitis, and herpes viruses.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug efficacy and reduce toxicity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies involving polymerases and kinases.
• Prodrug Development: Utilized to create prodrug forms designed to improve the bioavailability and targeting of active pharmaceutical ingredients.
• Labeled Compound Synthesis: Acts as a starting material for the synthesis of isotopically labeled (e.g., C13, N15) compounds for pharmacokinetic and metabolic studies.

Basic Information

Product Name	3'--Amino-2',3'-Dideoxyuridine
CAS No.	101062-04-8
Molecular Formula	C9H13N3O5
Molecular Weight	243.22 g/mol
Synonyms	3'-Amino-2',3'-dideoxyuridine; 2',3'-Dideoxy-3'-aminouridine; 3'-Amino-2',3'-dideoxy-Uridine; 1-[(2S,5R)-5-(Aminomethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; 3'-Amino-2',3'-ddU; 3'-NH2-2',3'-ddU; 3'-Amino-ddU
EINECS	Contact for details

Quality Control

Our 3'--Amino-2',3'-Dideoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.