Description

N'-Methyl-N(4)-Aminocytidine is a chemically modified nucleoside analog of cytidine, featuring methylation and amination at specific positions on the nucleobase. This structural modification is critical for its role as a key building block and intermediate in advanced pharmaceutical research and development. It is primarily utilized by research scientists and manufacturers in the life sciences sector, particularly those focused on oligonucleotide synthesis, antiviral drug discovery, and the development of novel therapeutic agents.

Application

• Oligonucleotide Synthesis: Serves as a modified phosphoramidite monomer for the solid-phase synthesis of therapeutic and diagnostic oligonucleotides, including antisense and siRNA molecules.
• Antiviral Research: Investigated as a precursor or active component in the development of nucleoside analog prodrugs targeting viral polymerases.
• Medicinal Chemistry: Used as a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and metabolic stability.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related biological pathways.
• Labeling & Diagnostics: Can be functionalized for use in probe development for various detection and diagnostic applications.

Basic Information

Product Name	N'-Methyl-N(4)-Aminocytidine
CAS No.	100997-69-1
Molecular Formula	C10H16N4O5
Molecular Weight	272.26 g/mol
Synonyms	4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methylpyrimidin-1-ium-1-ide; 1-(β-D-Ribofuranosyl)-4-amino-2-methylpyrimidin-2-one; 4-Amino-1-β-D-ribofuranosyl-2-methylpyrimidin-2(1H)-one; N4-Amino-2'-O-methylcytidine; 2'-O-Methyl-N4-aminocytidine; 4-Amino-2'-O-methylcytidine; Modified Cytidine Derivative; Nucleoside Intermediate
EINECS	Contact for details

Quality Control

Our N'-Methyl-N(4)-Aminocytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.