Description

3-Pyridinecarbonyl Chloride, 4-Chloro- (9Ci) is a versatile and reactive heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its ability to introduce the 4-chloronicotinoyl moiety, enabling the construction of complex molecules with high precision and efficiency. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require a reliable, high-purity intermediate for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where the chloronicotinate structure confers specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers, liquid crystals, and organic electronic materials requiring tailored heterocyclic components.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 4-Chloro- (9Ci)
CAS No.	100791-00-2
Molecular Formula	C6H3Cl2NO
Molecular Weight	176.00 g/mol
Synonyms	4-Chloronicotinoyl Chloride; 4-Chloropyridine-3-carbonyl Chloride; 4-Chloro-3-pyridinecarbonyl Chloride; 4-Chloronicotinic Acid Chloride; 3-Carbonylchloride-4-chloropyridine; 4-Chloro-nicotinoyl chloride; Isonicotinoyl chloride, 4-chloro-; 4-Chloro-3-pyridinylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarbonyl Chloride, 4-Chloro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.