Description

2-Thiopheneacetyl Fluoride, 4-Chloro-α-Oxo- (9Ci) is a specialized fluorinated thiophene derivative, serving as a high-value synthetic intermediate. Its molecular structure, featuring both a reactive acid fluoride group and a chloro-substituted thiophene ring, makes it a critical building block for constructing complex molecules in advanced research and development. This compound is primarily utilized by pharmaceutical and agrochemical R&D chemists for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides and fungicides with enhanced efficacy.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced organic electronic materials due to the thiophene moiety.
• Chemical Biology Probes: Employed in the creation of fluorophore-labeled probes and activity-based protein profiling (ABPP) reagents.
• Cross-Coupling Reactions: The acid fluoride group acts as an efficient coupling partner in palladium-catalyzed cross-coupling reactions for carbon-carbon bond formation.
• Peptide Mimetics: Used to introduce thiophene-based bioisosteres into peptide chains to modulate stability and biological activity.

Basic Information

Item	Detail
Product Name	2-Thiopheneacetyl Fluoride, 4-Chloro-α-Oxo- (9Ci)
CAS No.	100750-79-6
Molecular Formula	C7H4ClFO2S
Molecular Weight	206.62 g/mol
Synonyms	4-Chloro-2-thiopheneacetyl fluoride; 4-Chloro-2-thiopheneglyoxylic acid fluoride; 4-Chloro-2-thienylglyoxyloyl fluoride; 4-Chloro-α-oxo-2-thiopheneacetyl fluoride; 2-Thiopheneacetyl fluoride, 4-chloro-α-oxo-; (4-Chloro-2-thienyl)(oxo)acetyl fluoride; 4-Chloro-2-thiophenecarbonylformyl fluoride
EINECS	Contact for details

Quality Control

Our production of 2-Thiopheneacetyl Fluoride, 4-Chloro-α-Oxo- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques, including HPLC, GC, NMR, and IR spectroscopy, for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Light yellow to yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.