Description

Selenazofurin 5'-Triphosphate is a biologically active nucleotide analog, specifically the triphosphate derivative of the antiviral and anticancer nucleoside selenazofurin. This compound is of significant interest in biochemical and pharmacological research due to its role as a potential inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in *de novo* guanine nucleotide biosynthesis. It serves as a critical research reagent for studying nucleotide metabolism, antiviral mechanisms, and the development of novel therapeutic agents targeting proliferative diseases. Researchers in pharmaceutical development, enzymology, and molecular biology require this high-purity compound for *in vitro* studies and assay development.

Application

• Biochemical Research: Used as a substrate analog in enzymatic studies, particularly for investigating the activity and inhibition of inosine monophosphate dehydrogenase (IMPDH).
• Antiviral Mechanism Studies: Employed in research to elucidate the metabolic pathways and mechanisms of action of nucleoside-based antiviral agents.
• Oncology Research: Investigated as a potential chemotherapeutic agent due to its ability to disrupt nucleotide synthesis in rapidly dividing cells, such as cancer cells.
• Enzyme Kinetics & Assay Development: Serves as a standard or inhibitor in developing high-throughput screening assays for drug discovery targeting nucleotide metabolism.
• Metabolic Pathway Analysis: A tool for probing purine biosynthesis pathways in cell culture and *in vitro* systems.
• Pharmaceutical Reference Standard: Used as a certified reference material for quality control and analytical method validation in drug development pipelines.

Basic Information

Product Name	Selenazofurin 5'-Triphosphate
CAS No.	100647-95-8
Molecular Formula	C12H17N4O14P3Se
Molecular Weight	637.16 g/mol
Synonyms	2-β-D-Ribofuranosylselenazole-4-carboxamide 5'-Triphosphate; Selenazofurin TP; Selenazofurin Triphosphate; 1-(β-D-Ribofuranosyl)-1H-1,2,3-selenadiazole-5-carboxamide 5'-Triphosphate; NSC 368390; 2-β-D-Ribofuranosyl-4-selenazolecarboxamide 5'-Triphosphate; 5'-TP-Selenazofurin; EICAR 5'-Triphosphate Analog
EINECS	Contact for details

Quality Control

Our Selenazofurin 5'-Triphosphate is manufactured under strict quality protocols suitable for research applications. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay/purity by HPLC, identification by spectroscopic methods, and levels of critical impurities. Our quality commitment ensures the material meets the stringent requirements for reliable and reproducible scientific research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This compound is hygroscopic (moisture-sensitive); containers should be sealed under an inert atmosphere or desiccant and allowed to equilibrate to room temperature before opening to prevent moisture condensation. For long-term stability, store in a freezer.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.