Description

8-Aza-7-Deaza-2'-Deoxyguanosine is a modified nucleoside analog, a key building block in oligonucleotide synthesis. This compound matters for its role in creating stable, nuclease-resistant nucleic acid probes and primers used in advanced diagnostics and research. It is primarily needed by manufacturers in the pharmaceutical, biotechnology, and molecular diagnostics industries for applications in antisense therapy, PCR, and next-generation sequencing.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite monomer for the solid-phase synthesis of modified DNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate into oligonucleotides to enhance stability against enzymatic degradation and improve target binding affinity.
• Molecular Diagnostics: Essential for manufacturing probes and primers in PCR, qPCR, and other amplification techniques requiring high specificity and stability.
• Next-Generation Sequencing (NGS): Employed in the synthesis of specialized adapters or probes for genomic and transcriptomic analysis platforms.
• Biochemical Research: Serves as a tool for studying nucleic acid structure, function, and enzyme interactions.
• Aptamer Development: Used in SELEX processes to create modified aptamers with improved pharmacokinetic properties for therapeutic and diagnostic use.

Basic Information

Product Name	8-Aza-7-Deaza-2'-Deoxyguanosine
CAS No.	100644-70-0
Molecular Formula	C10H13N5O4
Molecular Weight	267.24 g/mol
Synonyms	7-Deaza-8-aza-2'-deoxyguanosine; 8-Aza-7-deaza-dG; Pyrrolo[2,3-d]pyrimidine-2'-deoxyribonucleoside; 2'-Deoxy-8-aza-7-deazaguanosine; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo[2,3-d]pyrimidine-7-carbonitrile; 8-Aza-7-deazaguanine deoxyriboside; c7N8-dG
EINECS	Contact for details

Quality Control

Our 8-Aza-7-Deaza-2'-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.