Description

Quinoline-8-carbonyl chloride is a versatile and highly reactive organic intermediate, primarily used as a key building block in the synthesis of more complex molecules. Its value lies in its ability to introduce the quinoline-8-carboxamide or quinoline-8-carboxylate moiety, which is a privileged structure in medicinal chemistry and materials science. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting neurological disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used to create novel fungicides, herbicides, and insecticides with the quinoline scaffold for enhanced efficacy.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal complexation.
• Functional Material Development: Employed in the research and production of advanced materials, such as organic semiconductors, fluorescent probes, and metal-organic frameworks (MOFs).
• Peptide Mimetics and Bioconjugation: Useful for modifying peptides or biomolecules to alter their properties or create diagnostic tools.
• Academic and R&D Laboratories: A valuable reagent for methodological development and exploratory synthesis in organic chemistry.

Basic Information

Product Name	Quinoline-8-carbonyl chloride
CAS No.	100517-41-7
Molecular Formula	C10H6ClNO
Molecular Weight	191.61 g/mol
Synonyms	8-Quinolinecarbonyl chloride; Quinoline-8-carboxylic acid chloride; 8-Quinolinecarboxylic acid chloride; 8-Carboxyquinoline chloride; 8-Quinolylcarbonyl chloride; 8-Quinolinecarbonylchloride; 8-Quinolinecarboxyl chloride
EINECS	Contact for details

Quality Control

Our Quinoline-8-carbonyl chloride is produced and tested under strict quality management protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.