Description

3-Piperidinemethanol, 4-(4-Fluorophenyl)-1-Methyl-, (3R,4R)- is a high-purity chiral piperidine derivative of significant importance in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D departments, process chemistry teams, and fine chemical manufacturers engaged in the synthesis of complex, stereoselective molecules targeting central nervous system (CNS) and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for CNS-active compounds.
• Asymmetric Synthesis: Utilized as a building block in stereoselective synthesis to introduce the (3R,4R)-configured piperidinemethanol scaffold.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development of commercial-scale synthetic routes for APIs.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Institutional Research: Applied in chemical and pharmacological research exploring new synthetic methodologies or biological targets.

Basic Information

Product Name	3-Piperidinemethanol, 4-(4-Fluorophenyl)-1-Methyl-, (3R,4R)-
CAS No.	100332-12-5
Molecular Formula	C13H18FNO
Molecular Weight	223.29 g/mol
Synonyms	(3R,4R)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol; (3R,4R)-4-(4-Fluorophenyl)-1-methylpiperidine-3-methanol; 4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol, (3R,4R)-; (3R,4R)-1-Methyl-4-(4-fluorophenyl)-3-piperidinemethanol; (3R,4R)-4-(p-Fluorophenyl)-1-methyl-3-piperidinemethanol; (3R,4R)-4-(4-Fluorophenyl)-1-methyl-3-piperidinylmethanol; (3R,4R)-4-(4-Fluorophenyl)-1-methyl-3-(hydroxymethyl)piperidine
EINECS	Contact for details

Quality Control

Our 3-Piperidinemethanol, 4-(4-Fluorophenyl)-1-Methyl-, (3R,4R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.