Description

8,5'-Cyclo(Deoxyadenosine 5'-Monophosphate) is a modified nucleoside monophosphate, a cyclized derivative of deoxyadenosine monophosphate (dAMP) that forms a covalent bond between the sugar and base moieties. This unique structural feature makes it a valuable tool for studying DNA damage and repair mechanisms, particularly those induced by oxidative stress and ionizing radiation. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleic acid chemistry, radiobiology, and the development of novel therapeutic agents.

Application

• Biochemical Research: As a stable, structurally defined lesion for investigating the biological processing of oxidatively damaged DNA.
• Radiobiology Studies: Serving as a critical standard and probe for understanding the formation and repair of DNA damage caused by free radicals.
• Enzyme Substrate/Inhibitor Studies: Used to characterize the specificity and activity of DNA repair enzymes, such as glycosylases and endonucleases.
• Pharmaceutical Development: A key intermediate or reference compound in the R&D of drugs targeting DNA repair pathways for oncology applications.
• Analytical Standard: Employed as a high-purity reference standard in LC-MS, HPLC, and other analytical methods for quantifying DNA adducts.
• Synthetic Chemistry: Used as a building block or model compound in the synthesis of modified oligonucleotides for diagnostic and therapeutic platforms.

Basic Information

Product Name	8,5'-Cyclo(Deoxyadenosine 5'-Monophosphate)
CAS No.	100217-00-3
Molecular Formula	C10H12N5O6P
Molecular Weight	329.21 g/mol
Synonyms	8,5'-Cyclo-2'-deoxyadenosine 5'-monophosphate; 8,5'-c-dAMP; 8,5'-Cyclo-dAMP; 5'-(Dihydrogen phosphate) 8,5'-cyclo-2'-deoxyadenosine; 8,5'-Cyclodeoxyadenosine 5'-monophosphate; 8,5'-Cyclo-2'-deoxyadenosine 5'-(dihydrogen phosphate); Cyclic DNA adduct standard; 8,5'-cA
EINECS	Contact for details

Quality Control

Our 8,5'-Cyclo(Deoxyadenosine 5'-Monophosphate) is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to meet the exacting requirements of the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.