Description

2-Thiopheneacetyl Chloride, 5-Methyl-α-Oxo- (9Ci) is a specialized heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its reactive carbonyl chloride group makes it an indispensable reagent for introducing the 5-methyl-2-thienylglyoxyloyl moiety into target molecules, enabling the creation of complex chemical architectures. This high-purity intermediate is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the thiophene ring contributes to biological activity.
• Material Science Research: Serves as a precursor for functional polymers and organic electronic materials due to the electron-rich thiophene unit.
• Peptide Mimetics & Conjugation: Employed in the synthesis of peptide analogs and for bioconjugation strategies, leveraging its reactive acid chloride functionality.
• Ligand & Catalyst Development: A valuable starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Essential for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	2-Thiopheneacetyl Chloride, 5-Methyl-α-Oxo- (9Ci)
CAS No.	100005-44-5
Molecular Formula	C8H7ClO2S
Molecular Weight	202.66 g/mol
Synonyms	5-Methyl-2-thienylglyoxyloyl Chloride; 5-Methyl-2-thiopheneglyoxylic Acid Chloride; 2-Thiopheneacetyl chloride, 5-methyl-α-oxo-; (5-Methyl-2-thienyl)(oxo)acetyl Chloride; α-Oxo-5-methyl-2-thiopheneacetyl Chloride; 5-Methylthiophene-2-glyoxylic Acid Chloride; 5-Methyl-2-thienylglyoxylic Chloride; 5-Methyl-2-thiophenecarbonylformyl Chloride
EINECS	Contact for details

Quality Control

Our production of 2-Thiopheneacetyl Chloride, 5-Methyl-α-Oxo- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting your quality management and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and highly volatile nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids, organic solvents, and incompatible materials.

Specification

Item	Specification
Appearance	Clear to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.