Description

α-2'-Deoxyguanosine is a modified nucleoside derivative, specifically a deoxyguanosine analog where the alpha anomer is present at the 2'-deoxyribose position. This compound is a critical building block and research tool in the fields of nucleic acid chemistry and medicinal chemistry. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in oligonucleotide synthesis, antiviral drug discovery, and the study of DNA structure and function.

Application

• Oligonucleotide Synthesis: Serves as a modified monomer for the solid-phase synthesis of antisense oligonucleotides, siRNA, and aptamers to modulate gene expression and study biological pathways.
• Antiviral Drug Development: Investigated as a precursor or analog in the research and synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand the mechanisms of DNA polymerases, nucleoside kinases, and other nucleic acid-metabolizing enzymes.
• Medicinal Chemistry: Acts as a key intermediate for the structural modification and development of novel nucleoside-based therapeutics targeting cancers and viral infections.
• Diagnostic Probe Development: Incorporated into labeled probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic techniques.

Basic Information

Product Name	α-2'-Deoxyguanosine
CAS No.	19916-78-0
Molecular Formula	C10H13N5O4
Molecular Weight	267.24 g/mol
Synonyms	2'-Deoxy-α-guanosine; α-dG; α-2'-Deoxyguanosine; 9-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one; α-Anomer of 2'-Deoxyguanosine; Guanosine, 2'-deoxy-, α-anomer; 2'-Deoxy-α-D-guanosine
EINECS	Contact for details

Quality Control

Our α-2'-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.